About Human Brain Interactome
Functional interactions between brain regions play a central role in cognitive computations. Evaluating such functional interactions in the human brain has been challenging due to the difficulties inherent to interrogating human brain activity at adequate spatiotemporal resolutions and with sufficient signal-to-noise ratio. Here we investigated pairwise interactions at a mesoscopic scale by quantifying the degree of coherence in intracranial field potential recordings from 4432 electrodes in 51 patients with pharmacologically intractable epilepsy over the course of 6360 hours. After correcting for artifacts and removing seizure events, we defined putative interactions by computing the coherence in different frequency bands between electrode pairs within each patient. We observed functional interactions that are consistent with known anatomical connectivity in the human brain, with macaque anatomical connections, and with neurophysiological interactions documented in macaque monkeys. These interactions showed strong stability across days. The interactions were also were also consistent across subjects. These results provide the first mesoscopic functional interactome of the human brain and constitute an important database to study modulations by state, by cognitive function, as well as by impairments due to neurological disorder.
Left-click and drag rotates the camera. Alternatively, the arrow keys and the "A","D" keys rotate the camera at a constant speed. Mouse wheel zooms the camera in and out. Alternatively, the "W","S" keys zoom the camera at a constant speed. Right-click and drag translates the camera.
Double-click or tap on a sphere to select an electrode, or one location in the average brain. Selecting the background resets the scene. Click or tap the pop-up bubble to reveal links to electrodes or locations in other brains. Selecting a line will highlight the electrode or location pair that gives rise to the significant interaction. The pop-up bubble contains information regarding the location, including the average coherence observed from that electrode, the number of significant interactions obeserved from the location, and the standard deviation of coherence. The brain region that the selected location belongs to is determined using the following atlases: Brodmann areas, Desikan-Killiany Atlas, Glasser-Van Essen Atlas, and Markov-Kennedy Atlas. Following a link from a location in the average brain to an electrode in the individual brain highlights the electrodes that make up the selected location in the average brain. Following a link back to the average brain highlights the location that includes the selected electrode in the individual brain.
The drop-down menu on the top-right corner of the interface with the default value "Broadband" controls which frequency band to show. Broadband is the default setting, showing functionally interacting locations or electrodes between 0 - 125 Hz. Theta: 3 - 8 Hz. Alpha: 8 - 12 Hz. Beta: 12 - 30 Hz. Gamma: 30 - 100 Hz.
The side panel on the right displays the subject number, the total number of electrodes, and the total number of days of recording in individual brains. Coherence values represent the average of the magnitude of coherence (the square-root of "magnitude-squared coherence") over the selected frequency band. Coherence values were calculated using Welch's method with time windows of 10 seconds at a sampling rate of 250 Hz. The circle-arrow button refreshes the page, remembering the selected locations the current scene is linked from. The home button returns to the average brain. The fullscreen button toggles fullscreen mode, or you can toggle fullscreen with the F11 key.
If you have any questions or comments, please contact Jiarui Wang: E-mail